Similar to the cancer type-dependent role of ST3GAL5, ST3GAL6 is upregulated in liver cancer and multiple myeloma, as well as the basal subtype of bladder cancer (Glavey et al., 2014; Hu et al., 2019; Dalangood et al., 2020), but downregulated in colorectal cancer (Sun et al., 2017). Here, ST3GAL5 is linked to cancer.