For example, ST3GAL6 overexpression is required for multiple myeloma cell homing to bone marrow niche and subsequent tumor growth (Glavey et al., 2014), while ST3GAL6 can induce AKT/mTOR signaling to promote hepatocellular carcinoma cell proliferation and invasion (Sun et al., 2017). This evidence concerns the gene MTOR and hepatocellular carcinoma.