In colorectal cancer cells, ST3GAL6-AS1 can recruit histone methyltransferase MLL1 to the promoter region of ST3GAL6 for histone H3K4me3 modification, thus activating the transcription of ST3GAL6 (Hu et al., 2019), while the interaction of ST3GAL6-AS1 with heterogeneous nuclear ribonucleoprotein A2B1 can also stabilize ST3GAL6 mRNA in multiple myeloma cells (Shen et al., 2021). This evidence concerns the gene PRDM9 and AL amyloidosis.