While many studies investigate the effect of potentiating protein and organelle homeostasis to scavenge intracytoplasmic neurotoxic aggregates and defective mitochondria, very little attention has yet been paid to explore the potential link between alteration in mitochondrial homeostasis and (in)stability of core components of the circadian clock in neurodegenerative conditions, PD in particular. Here, CLOCK is linked to Parkinson disease.