AGR2 and cancer: Regarding Agr2, consistent with our results, previous studies show that ROS can regulate its expression in regeneration and cancer contexts (Zweitzig et al., 2007; Chevet et al., 2013; Carbonell M et al., 2021) and nAG can promote regeneration of denervated limbs, as well as induce a high mitogenic response on blastema cells in newts (Kumar et al., 2007; Grassme et al., 2016).