With the roll-out of a national vaccination program, a significant proportion of the population now has exposure to COVID-19 vaccines.42,43 At present, such point-of-care testing should not be recommended for the evaluation of neutralising antibodies and vaccine efficacy; however, an immune response elicited by vaccination may affect the specificity of the IgG/IgM Rapid Test Cassette. The gene discussed is CD40LG; the disease is COVID-19.