The brain expression of 8 of the 10 Alzheimer-related genes had a significant correlation with brain metabolism across all four groups, and among them SORL1, FERMT2, CD33 and APOE showed a stronger absolute correlation with brain metabolism as risk for Alzheimer’s disease increased in CN participants (Fig. 3). This evidence concerns the gene SORL1 and early-onset autosomal dominant Alzheimer disease.