Metabolic processes regulate immune cell responses, and inappropriate immune activation can dysregulate cellular metabolism.20 Several groups have studied Alzheimer’s disease in the context of immunometabolism and suggested that defects in energy metabolisms caused microglia dysfunction in the disease.20,48MEF2C and TREM2 are associated with immunometabolism.49,50 The gene correlation observed in the present study supports the speculation that immune response and brain metabolism interact with each other through a set of risk genes for Alzheimer’s disease, contributing to disease development. This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.