In addition, because OPN signaling occurs through different integrin receptors, we also aimed to examine the relative mRNA expression profile of eight integrins (ITGA2, ITGA3, ITGA5, ITGA6, ITGA9, ITGAV, ITGB1, and ITGB3) and analyze the correlation of the relative expression of osteopontin variants and integrins in the same melanoma samples. The gene discussed is SPP1; the disease is melanoma.