Relative expression of integrins in melanoma tissue samples with distinct Breslow thicknesses varies, six integrins (ITGA3, ITGA6, ITGA9, ITGAV, ITGB1, and ITGB3) out of the eight showed a significant difference between the 2–4 mm and the > 4 mm group (lowest expression in the thickest group), and again, expression of ITGA2 showed a significant decrease as the thickness increased. The gene discussed is ITGB3; the disease is melanoma.