Clinically, the hepatotoxicity caused by TwHF and its preparations containing TP is mainly manifested as acute hepatitis, with symptoms such as nausea, fatigue, anorexia, increased serum alanine transaminase (ALT)and aspartate aminotransferase (AST) levels, and obvious cholestasis (Yang et al., 2018). The gene discussed is GPT; the disease is Acute hepatitis.