Ginsenoside Rg3 prevented cognitive impairment in a rat AD model (Zhang et al., 2019) and Notopterol effectively ameliorated cognitive deficits in APP/PS1 mice by attenuating pathology caused by the accumulation of amyloid-β and tau (Jiang X. et al., 2020; Jiang X. W. et al., 2020). This evidence concerns the gene MAPT and Cognitive impairment.