Therefore, we used WP1066 (Beyotime, China), a specific inhibitor of STAT3 phosphorylation, and FR180204 (Beyotime, China), a specific inhibitor of ERK phosphorylation, to provide evidence that rhein inhibits the myocardial hypertrophy cell phenotype by targeting p-STAT3 and P-ERK (Figure 3F). This evidence concerns the gene STAT3 and cardiac hypertrophy.