RORC and acute kidney injury: Similarly, in a separate study, autophagy was found to have a possible role in promoting renal fibrosis: in severe acute kidney injury, tubular cells undergo arrest in the G2/M phase, leading to the secretion of pro-fibrotic factors that promotes the progression of renal fibrosis, accompanied by the emergence of TOR-autophagic spatially coupled compartments structures (distinct cytoplasmic compartments rich in mTORC1) (Yang et al., 2010; Canaud et al., 2019; Tang et al., 2020).