In DKD mice and renal tubular epithelial cell models, treatment with LNA-anti-miR-214 or overexpression of Klotho (an anti-aging factor expressed in the kidney) modulated the P53/miR-214/ULK1 and AMPK/ERK signaling pathways to exert nephroprotective effects (Ma et al., 2020; Xue et al., 2021). The gene discussed is ULK1; the disease is diabetic kidney disease.