In addition, it has been shown that the expression of cytochrome P450 oxidoreductase (POR), a positive regulator of ferroptosis, is significantly increased in G6PD knockdown hepatocellular carcinoma (HCC) cells, which suggests that G6PD may inhibit ferroptosis through POR (Cao et al., 2021). The gene discussed is POR; the disease is hepatocellular carcinoma.