Xin et al. (2019) found that lncRNA HULC promoted autophagy and enhanced DDP resistance in GC cells. Our group previously reported that lncRNA NORAD could enhance autophagy flux by the miR-433–3p/ATG5-ATG12 axis leading to oxaliplatin resistance (Wang et al., 2021). The gene discussed is HULC; the disease is gastric cancer.