IL6R and cholangiocarcinoma: In addition, multivariate analysis showed that a high expression of IL-6R and high tumor staging could be used as independent prognostic factors of clinicopathological characteristics for overall survival of CCA patients (p = 0.017; HR = 1.731; CI = 1.103–2.716 and p = 0.014; HR = 1.548; CI = 1.093–2.192, respectively) (Table 2).