FDPS and osteoporosis: ZA is known as the gold standard for the treatment of osteoporosis because of its recognized role in attenuating bone resorption and osteoclast apoptosis by inhibiting FPPS in the mevalonate pathway (Figure 2) (Tang et al., 2017; Zameer et al., 2018; Chandra and Rajawat, 2021; Chen et al., 2021; Munoz et al., 2021).