INS and type 2 diabetes mellitus: Further, a double-blinded, placebo-controlled, clinical trial of twenty-four type 2 diabetic subjects supplied with Momordica charantia L. juice or placebo for 3 months showed a reduction in body weight, HbA1c and blood serum glucose, and increase in insulin secretion of the experimental subjects compared to placebo (Cortez-Navarrete et al., 2018).