Thus, future screening of antidiabetic compounds in natural product libraries/databases with computational tools such as Schrödinger Maestro tools and Autodock tools and evaluating their bioactive synergistic characteristics in vitro on digestive enzymes (α-amylase or α-glucosidase), GLUT4, GLUT2 and other enzymes involved in regulation of blood glucose can unveil novel compounds for diabetes mellitus treatment. This evidence concerns the gene SLC2A2 and diabetes mellitus.