In addition to correlative observation of aggressive DU145 and PC3M prostate cancer cells with high MTA1/miR-22 and low E-cadherin expression compared to “good” RWPE1 and LNCaP cells, meta-analysis of patient tumor samples indicated a positive correlation between MTA1 and miR-22 and a negative correlation between MTA1 and E-cadherin, supporting their inhibitory effect on E-cadherin expression. The gene discussed is MTA1; the disease is Familial prostate cancer.