For example, a recent study demonstrated that miR-149 could inhibit AR expression and reduce the activity of PI3K/Akt1 signaling in castrate-resistant cells (Zhao et al., 2021) and also regulate RGS17-mediated oncogenic effects (Ma et al., 2021) revealing its tumor suppressor nature in prostate cancer. This evidence concerns the gene AKT1 and Familial prostate cancer.