Mechanistically, MTA1-induced overexpression of miR-22 reduced expression of E-cadherin resulting in increased cell invasiveness and migration of prostate cancer cells and the link between miR-22 and its putative target E-cadherin mRNA was demonstrated using reporter constructs of the 3ˊ-UTR of E-cadherin. This evidence concerns the gene CDH1 and Familial prostate cancer.