Both resveratrol and pterostilbene inhibited survival pathways and induced apoptosis in prostate cancer through downregulation of the MTA1/HDAC1, 2 units of the NuRD complex, which resulted in the promotion of acetylation and reactivation of tumor suppressors p53 and PTEN (Kai et al., 2010; Dhar et al., 2015b). This evidence concerns the gene PTEN and Familial prostate cancer.