Our special interest in oncomiR/PTEN axis came from previous studies, in which we and others showed upregulation of PTEN protein levels by resveratrol in prostate cancer cells (Wang et al., 2010; Dhar et al., 2011), one mechanism of which was the inhibition of MTA1-mediated deacetylation and inactivation of PTEN (Dhar et al., 2015a). This evidence concerns the gene MTA1 and Familial prostate cancer.