In a different set of experiments using a high-risk premalignant prostate cancer mouse model (R26MTA1; Pten+/f; Pb-Cre+) fed a diet supplemented with pterostilbene (100 mg/kg diet), we registered MTA1-targeted chemoprevention along with reduced circulating miR-22 and miR-34a levels in response to pterostilbene treatment (Hemani et al., 2022). Here, PTEN is linked to Familial prostate cancer.