E-cadherin is considered as an inhibitor of tumor migration and invasion through maintaining an epithelial phenotype, while Snail is an important promoting factor of epithelial-mesenchymal transition (EMT), which plays a key role in the EMT pathway associated with tumor invasion and metastasis (Chatterjee et al., 2017; D'Alterio et al., 2020; Giannelli et al., 2016). The gene discussed is CDH1; the disease is neoplasm.