Moreover, the expression level of DNMT also changed with tumor differentiation, from 52.9% to 68.4% (p = 0.543) for DNMT1, 29.4%–68.4% (p = 0.045) for DNMT3A, and 5.9%–31.6% (p = 0.128) for DNMT3B when changing from Gleason less than or equal to six to Gleason 7, of which only DNMT3A expression differences were significant, with a Gleason score of 8–10, DNMT1 (p = 0.252) and DNMT3A (p = 0.016) expression was 100% and DNMT3B expression was 66.7% (p = 0.033) (Gravina et al., 2011). Here, DNMT3A is linked to neoplasm.