DNMT1 and osteosarcoma: It is well-documented that DNMT1 is an oncoprotein in both solid and hematological malignancies (Pathania et al., 2015; Wong et al., 2019), and DNMT1 has been reported to exert oncogenic effects in multiple cancers, such as BC (Li H. et al., 2020; Zhu et al., 2022), lung cancer (Wu et al., 2020), colon cancer (Chen et al., 2019), and osteosarcoma.