Moreover, research from several sources has identified that hyperexpression of DNMT3A was associated with malignant characteristics of vulvar squamous cell carcinomas (Leonard et al., 2016), pituitary adenomas (Ma et al., 2018), and colorectal cancer (CRC) (Zhang et al., 2022), such as high invasion and migration. The gene discussed is DNMT3A; the disease is pituitary gland adenoma.