WNK2 and cancer: Therefore, the researchers focused on the role of DNMTs on cancer at a molecular level and found that the mitogen-activated protein kinase (MAPK) signaling pathway, the ubiquitous, growth factor-regulated phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, as well as the Wnt/β-catenin signaling pathway, were activated in the development of cancer.