However, DNMT3A counteracted the inhibitory effect of miR-101 on the invasive migration of lung cancer cells and also disrupted the miR-101-activated caspase-3 (an apoptotic enzyme) (Yan et al., 2014), which led to the inhibition of NSCLC proliferation (Wang L. et al., 2017). The gene discussed is DNMT3A; the disease is lung carcinoma.