DNMT3B and cancer: However, studies have previously reported that DNMT3B was an oncogene that played a crucial role in the progression of various types of cancer, including endometrial cancer (EC) (Gui et al., 2021), lung cancer (Yang et al., 2014), and PCa(Agarwal et al., 2013), and conversely DNMT3B has implicated as a TSG in lymphoma (Hlady et al., 2012).