Specifically, the four typical “hot” property herbs might influence hypothyroidism by (i) acting on the PI3K-Akt signaling pathway, Ca 2+- AMPK signaling pathways to promote lipid metabolism and energy metabolism; (ii) promoting thyroid hormone synthesis through purine metabolism; (iii) acting on the tryptophan metabolism to improve the declined energy metabolism and thyroid hormone levels. Here, AKT1 is linked to hypothyroidism.