Finally, we analyzed the association of prognostic gene expression with tumor stemness, N6-methyladenosine (m6A) mRNA status, and cancer chemoresistance to bring a novel perspective on predicting the prognosis and improving treatment strategies for patients with LGG; and identified MSR1, associated with the migration, invasion, epithelial–mesenchymal transition (EMT), and proliferation of LGG cells, as a potential drug target. Here, MSR1 is linked to neoplasm.