We compared the gene mutation information of NLRP3 and PBX1 in HCC (data from TCGA, PanCancer Atlas with 372 samples) and LUAD (data from TCGA, PanCancer Atlas with 566 samples) through the cBioPortal database (https://www.cbioportal.org/) and analyzed the relationship between HAL-related driver gene mutations. The gene discussed is PBX1; the disease is hepatocellular carcinoma.