The synonymous mutation (c.1299C>A) in NLRP3 was archived in the COSMIC database from a lung adenocarcinoma tumor sample (TCGA-50-5941-01), and the nonsynonymous mutations of neither NLRP3 nor PBX1 were archived in dbSNP, 1,000 Genomes Project, ExAC database, and COSMIC. This evidence concerns the gene NLRP3 and lung adenocarcinoma.