NLRP3 is altered in 11% of 566 cases in the mutation data from TCGA-LUAD samples and 2.2% of 366 cases in the mutation data from TCGA-HCC samples, and PBX1 is altered in 1.8% of 566 cases in the mutation data from TCGA-LUAD samples and 1.6% of 372 cases in the mutation data from TCGA-HCC samples. The gene discussed is PBX1; the disease is hepatocellular carcinoma.