TP53 and hepatocellular carcinoma: After comparing the co-expression information between mutated NLRP3, PBX1, FAT1, EGFR, KRAS, and TP53 in HCC and LUAD tissues through the cBioPortal database, we found that the samples with both NLRP3 and TP53 mutations were the most in LUAD (Figure 8).