Considering that obesity can alter levels of adipokines, pro-tumorigenic lipids, and metabolites, and since lipid accumulation is an established causal risk factor in our study, it might be reasonable that the previously observed association between obesity and CCA, especially for iCCA, could be mediated by LFC (Osataphan et al., 2021). Here, PRRT2 is linked to obesity due to melanocortin 4 receptor deficiency.