When the Wnt signalling pathway is activated, AKT is phosphorylated to form phosphorylated AKT with kinase activity, which can inactivate GSK-3β by phosphorylating GSK-3β to form phosphorylated GSK-3β, causing reduced degradation of intracellular β-catenin to promote apoptosis of cancer cells (Katoh and Katoh, 2017; Zhang et al., 2017). The gene discussed is AKT1; the disease is cancer.