Senomorphics are a group of SASP regulators, which can alleviate renal senescence in CKD (Schroth et al., 2020) by modulating a variety of pathways, such as MAPK, mTOR, NF-κB and NRF2 pathways (Iwasa et al., 2003). The gene discussed is NFE2L2; the disease is chronic kidney disease.