DDIT4 and gastric cancer: In addition, a clinical data from Taiwan verified that Chinese Angelica could prolong the survival rate of GC patients [adjusted hazard ratio (HR) 0.72 [95% CI, 0.57–0.92] (p = 0.009)], and experimental studies also found that N-butylidenephthalide (BP), the active component of Chinese Angelica, could induce increased REDD1 expression, inhibit mTOR signaling, activate apoptosis through the mitochondrial pathway, and inhibit the proliferation and EMT of AGS, NCI-N87, and TSGH-9201 cells (Liao et al., 2018).