In one study evaluating the anti-tumor activity of APS combined with adriamycin in human GC cell SGC-7901 and SGC-7901/ADR, the results showed that APS reduced cell viability and enhanced the rate of apoptosis in a time-dosage dependent manner, up-regulated p-AMPK and caspase-3 expression levels, induced apoptosis through the AMPK pathway, and improved the sensitivity of GC cells to adriamycin, suggesting that APS can be used as a chemosensitizer (Song et al., 2020). Here, CASP3 is linked to gastric cancer.