Network pharmacology and experimental validation suggested that Sijunzi decoction could inhibit tumor proliferation and angiogenesis by down-regulating the expression of VEGFA, iNOS, COX-2, and Bax/Bcl2 proteins in NCG-bearing mice with human gastric adenocarcinoma cell NUGC-4, regulate the PI3K/AKT pathway, and induce apoptosis (Ding et al., 2022). Here, AKT1 is linked to neoplasm.