For another example, 18β-glycyrrhetinic acid (18β-GA) can inhibit MMP-2 and MMP-9 activities in a dose-dependent manner, up-regulate E-cadherin expression and down-regulate vimentin expression, and reduce the metastatic potential of human GC cell line SGC-7901 cells through ROS/PKC-α/ERK signaling pathway and inhibition of EMT (Cai et al., 2018). This evidence concerns the gene PRKCA and gastric cancer.