In 2009, Richard et al. speculated that DSF should be studied as an adjuvant to chemotherapy for glioblastoma based on its effect on acetaldehyde dehydrogenase (ALDH) in glioma (Kast and Belda-Iniesta, 2009), and since then the value of DSF in glioma has been focused. This evidence concerns the gene LDHA and glioblastoma.