SREBF1 and neoplasm: PARPi treatment induces macrophage differentiation to M2 phenotype under the mediation of sterol regulatory element-binding protein 1 (SREBP1) and promotes the expression of colony-stimulating factor receptor (CSF-1R) required for self-survival, while CSF- 1R-positive macrophages inhibit the function of T cells and promote tumor growth and invasion.