Tat-NR2B9c, a blocker of NMDAR-postsynaptic density protein-95 (PSD95), exerts a neuroprotective effect on stroke by activating Ca2+ dependent pathways and enhancing calmodulin-dependent protein kinase type IV (CaMKIV) and CREB (Bell et al., 2013). The gene discussed is DLG4; the disease is Stroke.