Previous studies also revealed resiquimod-induced lymphopenia in CD-1 mice, more specifically, a decrease in the counts of circulating lymphocytes recapitulating clinical and experimental observations of acute viral infection (46–48), including after TLR7 stimulation (49) that was also found in SARS-CoV-2 patients (22, 50). The gene discussed is TLR7; the disease is lymphopenia.