Therefore, we hypothesized that the abnormal activation of the TLR4/NF-κB/NRLP3 signaling pathway will promote pyroptosis in the smooth muscle cells of the airway, mediate caspase-1-dependent pyroptosis in the smooth muscle cells of the airway, cause a strong inflammatory response, and induce BA. Here, NFKB1 is linked to breast angiosarcoma.