Song et al. performed acupuncture at Baihui acupoint and Zusanli acupoint on the ipsilateral side of cerebral ischemia-reperfusion model rats, and found that both IL-1β and ICAM-1 in the brain region of the healthy side of the rats showed a trend of increasing, which was statistically different from that of the model group [61]. This evidence concerns the gene ICAM1 and brain ischemia.