MMP3 and colon adenocarcinoma: Univariate Cox regression analysis yielded 23 JW-targeted genes associated with the survival in COAD patients (Figure 5(c)), and the least absolute shrinkage and selection operator (Lasso) regression analysis selected 13 genes as prognostic signatures (TPSG1, ITLN1, INHBB, SLC4A4, SFRP2, RN7SL3, GRP, MMP10, PLIN1, MMP3, NDUFB1P1, TFF1, and CD177) (Figure 5(d)) (Supplementary Table 4).