TP53 and cancer: The top 20 of KEGG enrichment pathways contained pathways in cancer related to cell cycle, focal adhesion, adherens junction, and apoptosis, such as Wnt, PPAR, cAMP, mTOR, Jak-STAT, p53, TGF-beta, HIF-1, VEGF, MAPK, and PI3K-Akt signaling pathways, which all participated in tumorigenesis and metastasis (Figure 3(b)).