According to the COVID-19 vaccine candidates' solution devised by WHO, the research and development scheme of the vaccine primarily focused on spike (S) protein, a glycosylated trimer that protrudes from the SARS-CoV-2 lipid envelope (7, 8), since two important processes of SARS-CoV-2 entering host cells, including receptor identification and subsequent membrane fusion, are mainly mediated by S protein. The gene discussed is PROS1; the disease is COVID-19.