In recent experimental studies, it has been observed that the loading the neurotrophic factors BDNF and GDNF into scaffolds of various composition enhances peripheral nerve regeneration in spinal cord injury (Tom et al., 2018; Hassannejad et al., 2019; Tajdaran et al., 2019; Ji et al., 2020; Cacialli, 2021), improve the survival and proliferation of transplanted neural cells (Nakaji-Hirabayashi et al., 2009; Wang et al., 2011) and provide the positive dynamics in brain tissue recovery in experimental stroke (Moshayedi et al., 2016; Cook et al., 2017). Here, GDNF is linked to Stroke.