In the high-fat diet-induced obesity mouse model, CXCL10 expression in skeletal muscle is increased, and the capillary density is decreased, while after aerobic training, CXCL10 expression is reduced, and the capillary density is increased (Ishiuchi-Sato et al., 2020). This evidence concerns the gene CXCL10 and obesity due to melanocortin 4 receptor deficiency.