TIMP2 and acute kidney injury: [TIMP-2] x [GFBP-7] values >0.3 were highly linked with the development of AKI (OR 11.8, p < 0.001) upon ICU admission, with a sensitivity of 0.60 and specificity of 0.88, whereas measurements before surgery (baseline) were not associated with the risk of AKI (Oezkur et al., 2017).