TIMP2 and acute kidney injury: Meersch et al. measured TIMP2-IGFBP7 concentrations in serial urine samples from 50 patients undergoing cardiac surgery; changes in creatinine and urine volume did not occur until 1–3 days postoperatively, whereas TIMP2-IGFBP7 concentrations began to rise as early as 4 h postoperatively in patients who had AKI, and the 4-h postoperative cutoff value demonstrated positive sensitivity and specificity, with an area under the ROC curve of 0.81 (CI: 0.68–0.93).