TIMP2-IGFBP7 was significantly raised in >10% of patients in the low-risk CI-AKI population, indicating structural kidney injury, while serum creatinine remained silent, thus revealing subclinical CI-AKI (SCI-AKI), according to a study on contrast-induced AKI (CI-AKI). The gene discussed is IGFBP7; the disease is acute kidney injury.