TIMP-2, a 21 KDa protein with anti-apoptotic and proliferative properties, and IGFBP7, a 29 KDa protein and IGF-1 receptor antagonist, cause tumor suppression and regulate cellular aging by inhibiting kinase signaling.TIMP-2 and IGFBP7 are both inducers of G1 cell cycle arrest. The gene discussed is TIMP2; the disease is neoplasm.