HAVCR1 and acute kidney injury: KIM-1 in urine has the potential to be a helpful biomarker for subclinical AKI associated with obstruction, according to Olvera-Posada et al. The significance lies not only in the ability to identify an obstruction marker in urine but also in the ability to quantify the grade of renal impairment to modify the treatment paradigm (Olvera-Posada et al., 2017).