NEDD4L and melanoma: NEDD4L transcripts exist in many tissues, especially in liver, kidney, heart and lung (Dunn et al., 2002; Araki et al., 2008), and NEDD4L is down-regulated in melanoma (Cui et al., 2020), colorectal cancer (Yang et al., 2020), lung cancer (Wang et al., 2019) and other cancers, indicating NEDD4L is a tumor suppressor.