CACNA1C and hypertensive disorder: For instance, studies associate changes in CaV1.2 function with increased myogenic tone in conditions such as hypertension (Nieves-Cintron et al., 2008; Navedo et al., 2010a) and diabetes (Navedo et al., 2010b; Nystoriak et al., 2014; Nystoriak et al., 2017a).