We showed that there was no difference in mRNA expression of IGFBP-1, IGFBP-2, or IGFBP-3 in the liver or skeletal muscle after a 1-week infusion of oIGF-1 compared to SAL in the setting of fetal hypoinsulinemia and lower amino acid concentrations. This evidence concerns the gene IGFBP3 and Hypoinsulinemia.