MuRF1 and Atrogin1 are important ubiquitin ligases in the ubiquitin-proteasome pathway that mediate muscle proteolysis, and here, we found that their corresponding gene expressions of MuRF1 and Atrogin1 were significantly upregulated in skeletal muscles of COPD mice (Figure 2F). The gene discussed is TRIM63; the disease is chronic obstructive pulmonary disease.