TBX15 and metabolic disease: Furthermore, in the Common Metabolic Diseases Knowledge Portal, the TBX15-WARS2 locus is associated with cardiovascular traits such as stroke severity and peripheral vascular disease in people with type 2 diabetes (cmdgenkp.org, 2021a), whilst variants in the WARS2 gene are linked to diastolic blood pressure (cmdgenkp.org, 2021b).