KLF2 and congestive heart failure: In particular we were interested in expression of the shear stress-sensitive transcription factor Kruppel-like Factor 2 (KLF2), as KLF2 controls expression of mediators of antioxidant defense, nitric oxide production, and tissue fibrosis (Dekker et al., 2005; Boon et al., 2007; Fledderus et al., 2008) and has previously been shown to be downregulated in animal models of CHF (Haack et al., 2014; Del Rio et al., 2017; Marcus et al., 2018).