OPN1MW and congestive heart failure: As shown in Figure 6B, mRNA expression of fibrosis repressing genes KLF15 (4.46 ± 1.02 f.c. sham, 1.80 ± 0.57 f.c. CHF, 2.33 ± 0.85 f.c. CHF-CBD, KWS 6.37), E Cadherin (4.65 ± 1.12 f.c. sham, 0.84 ± 0.22 f.c. CHF, 1.09 ± 0.48 f.c. CHF-CBD, KWS 11.82), and KLF4 (0.69 ± 0.06 f.c. sham, 0.19 ± 0.10 f.c. CHF, 0.40 ± 0.22 f.c. CHF-CBD, KWS 8.82) were reduced in CHF and CHF-CBD relative to sham, however CHF and CHF-CBD were not significantly different from each other (p > 0.05).