OPN1MW and congestive heart failure: As show in Figure 4 baseline cortical RPO2 was significantly lower in CHF relative to sham (p < 0.05), and this effect was attenuated in CHF-CBD as cortical RPO2 in this group was significantly higher (p < 0.05) than in CHF (RPO2 41 ± 3 mmHg sham, 28 ± 2 mmHg CHF, 37 ± 2 mmHg CHF-CBD, F 7.522 DF 2,27).