Despite improvements in RBF that occurred with CBD, we did not observe significant increases in expression of KLF2, NRF2, NQO1, or eNOS mRNA in CHF CBD tissue, suggesting that either the improvement in RBF and RPO2 was not sufficient to reverse changes in gene expression or that additional factors not affected by CBD impinge on these pathways. The gene discussed is NOS3; the disease is congestive heart failure.