The decrease in GFR from pre to post was significantly greater (p < 0.05) in CHF vs. sham, and significantly less (p < 0.05) in CHF-CBD vs. CHF (−0.05 ± 0.03 sham, −0.45 ± 0.08, CHF, −00.21 ± 0.03 CHF-CBD, one way ANOVA and Sidak Holm multiple comparison test, F 12.91 DF 2,27, Figure 2B). Here, OPN1MW is linked to congestive heart failure.