OPN1MW and congestive heart failure: As show in Figure 5, nadir RBF and RPO2 during IA were significantly lower in CHF than sham (p < 0.05), and this effect was attenuated (p < 0.05) by CBD for RBF (RBF 7.0 ± 0.1 ml/min sham, 4.8 ± 0.1 ml/min CHF, 6.0 ± 0.1 ml/min CHF-CBD, F 257.6 DF 2,27) but not RPO2 (25 ± 0.2 mmHg sham, 17 ± 0.2 mmHg CHF, 17 ± 0.2 mmHg CHF-CBD, F 634 DF 2,27).