The major findings of the study were as follows: 1) TGF-β2 ameliorated the abnormal expression of pro-inflammatory markers in adipose tissue, but had no effects on the glucose intolerance, anxiety-like behaviors, or low hippocampal BDNF and nNOS expression of db/db mice; and 2) the hippocampal BDNF and nNOS protein levels correlated with the expression of the pro-inflammatory gene Tnfa, but not Il6, in adipose tissue. The gene discussed is NOS1; the disease is Glucose intolerance.