The multivariate Cox regression analyses showed the combination of SMI‐low and low‐CD3 or CD8 were independent predictors of RFS in CRC patients (SMI/CD3 TILs: hazard ratio [HR] = 2.90, 95% CI = 1.82–4.62, P < .001; SMI/CD8 TILs: HR = 3.01, 95%CI = 1.84–4.90, P < .001; Table 3). Here, CD8A is linked to colorectal carcinoma.