Three Subjects with VUS were identified: SDHA: SDHA c.1579C>T in Subject 11, or SDHC:c.430G>C in Subjects 12 and 13, with respectively the diagnosis of gastric adenocarcinoma, retroperitoneal leiomyosarcoma, and uterine adenosarcoma (Table 2). The gene discussed is SDHC; the disease is retroperitoneal leiomyosarcoma.