The query revealed six Subjects (Subject 5 - Subject 10) positive for germline VUS in PMS2 or MSH6 genes who had non-Lynch related tumors of cholangiocarcinoma, lung adenocarcinoma, clear cell renal cell carcinoma, serous type endometrial adenocarcinoma, and urothelial carcinoma (Tables 1, 2). The gene discussed is MSH6; the disease is clear cell renal carcinoma.