The query revealed six Subjects (Subject 5 - Subject 10) positive for germline VUS in PMS2 or MSH6 genes who had non-Lynch related tumors of cholangiocarcinoma, lung adenocarcinoma, clear cell renal cell carcinoma, serous type endometrial adenocarcinoma, and urothelial carcinoma (Tables 1, 2). Here, PMS2 is linked to clear cell renal carcinoma.