We sought to evaluate individuals with rare germline VUS in MMR genes (PMS2, MLH1, MSH2, or MSH6), SDHx genes (SDHA, SDHB, SDHC, SDHD, or SDHAF2), and TP53 gene in individuals who are suspected of having LS, hereditary PGL/PCC, and LFS, respectively. The gene discussed is MSH2; the disease is adrenal gland pheochromocytoma.