MMR-P/MSS, intact IHC, and absence of biallelic inactivating of MSH6 rule out lynch-related endometrial cancer.Somatic alterations consistent with sporadic serous-like endometrial carcinoma and uterine carcinoma: PIK3CA:c.1635G>T (p.Glu545Asp); TP53:c.817C>T (p.Arg273Cys); gain of  3q26.2; Low copy number gain of CCNE1 at 19q12. The gene discussed is PIK3CA; the disease is endometrial carcinoma.