Somatic alterations consistent with sporadic RCC: VHL:c.266T>A (p.Leu89His); PBRM1:c.292dupC (p.Gln98Profs*10); low level gain of a portion of chromosome 5q; one copy loss of chromosome 3p (including VHL, SETD2, and PBRM1). Here, SETD2 is linked to renal cell carcinoma.