Somatic OncoPanel identified the following somatic variants in MSH6: c.3253_3254insC (p.F1088Lfs*5); c.3556+2T>C; and c.3173A>T (p.D1058V) The Revised Bethesda criteria were met for this patient based on his diagnosis of colorectal cancer under age 50. The gene discussed is MSH6; the disease is colorectal cancer.