ICLs are recognized during S phase, mainly by the UHRF1 protein which, together with an anchor complex composed of Fanconi Anemia Complementation Group M (FANCM) and FAAP24, ensure the recruitment of the FA core complex and the FANCD2-I heterodimer to the appropriate location in the chromatin (14). The gene discussed is FANCM; the disease is Fanconi anemia.