However, very high concentrations of extracellular ATP (5-10 mM) are required to activate the cytotoxic activity of the P2X7 receptor, and although these concentrations are probably achieved following classical anticancer therapies that lead to necrosis, such as chemotherapy or radiotherapy, they are rarely present in the untreated tumor microenvironment (TME) due to the activity of ubiquitous ectonucleotidases (3, 8). Here, P2RX7 is linked to neoplasm.