They have been reported in 5% of all RET-mutated sporadic MTCs, as reported in the Catalogue of Somatic Mutations in Cancer (COSMIC database: https://cancer.sanger.ac.uk/cosmic, accessed June 2022), and they represent around 3.5% of all germlines RET alterations found in MEN2 patients, as reported in the ARUP database (https://arup.utah.edu/database/MEN2/MEN2_display.php accessed June 2022). The gene discussed is RET; the disease is cancer.