RET rearrangements occur in 10–20% of papillary thyroid carcinomas (PTCs), 1–2% of non-small cell lung cancers (NSCLCs), and in <1% of other cancers (e.g., colorectal cancer, breast cancer, chronic myelomonocytic leukemia, ovarian and salivary gland cancers, etc.)(11). The gene discussed is RET; the disease is non-small cell lung carcinoma.