In addition, another group of researchers found that circ-Foxo3 and its parental gene Foxo3 (forkhead box O3) was lowly expressed in AML tumor cells than that in bone marrow nucleated cells, and the overall survival time of AML patients with high Foxo3 expression was longer than those with low Foxo3 expression. The gene discussed is FOXO3; the disease is acute myeloid leukemia.