The apoptosis and cell cycle of tumor cell played important roles in tumor growth (62), recent studies had found that circFBLIM1 could function as a ceRNA to upregulate host gene FBLIM1 expression through sponging miR-346 and thus exert inhibitory effect in tumor cells apoptosis in hepatocellular cancer; circ-MAPK4 silencing had also been confirmed to downregulate its parental gene expression through ceRNA mechanism, resulting in upregulated phosphorylation level of P38/MAPK (mitogen-activated protein kinase) in glioma tumor cells and promoting tumor cells apoptosis (21, 22). Here, MAPK4 is linked to neoplasm.