Through the usage of high-throughput RNA sequencing, a large number of circRNAs were found to be able to regulate cancer-related signaling pathways by affecting host gene expressions such as, circ-PTEN increased its particular parental gene PTEN (phosphatase and tensin homolog) expression by acting as the molecular sponge for miR-155 and miR-330-3p, resulting in non-small cell lung cancer cells growth inhibition and the inactivation of the carcinogenic PI3K/AKT signalling pathway, an important regulatory pathway of signalling and intracellular vesicular trafficking (32, 67). Here, PTEN is linked to cancer.